Annals of Indian Academy of Neurology
EDITORIAL COMMENTARY
Year
: 2020  |  Volume : 23  |  Issue : 4  |  Page : 428-

Non-motor symptoms in cervical dystonia: A concept in evolution


Daniele Urso, Valentina Leta, K Ray Chaudhuri 
 King's College London, Department of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park; Parkinson's Foundation Centre of Excellence, King's College Hospital, Denmark Hill, London, United Kingdom

Correspondence Address:
Daniele Urso
Institute of Psychiatry, Psychology and Neuroscience, Department of Basic and Clinical Neuroscience, The Maurice Wohl Clinical Neuroscience Institute, Kingfs College London, Cutcombe Road, London SE5 9RT
United Kingdom




How to cite this article:
Urso D, Leta V, Chaudhuri K R. Non-motor symptoms in cervical dystonia: A concept in evolution.Ann Indian Acad Neurol 2020;23:428-428


How to cite this URL:
Urso D, Leta V, Chaudhuri K R. Non-motor symptoms in cervical dystonia: A concept in evolution. Ann Indian Acad Neurol [serial online] 2020 [cited 2020 Oct 25 ];23:428-428
Available from: https://www.annalsofian.org/text.asp?2020/23/4/428/289833


Full Text



Non-motor symptoms (NMS) are now recognized as a key determinant of quality of life and disability in movement disorders, independent in their own right and not merely a secondary accompaniment to motor symptoms. NMS are well-characterized in the natural history of Parkinson's disease,[1] but are also being increasingly reported in other movement disorders, including all forms of dystonia. Although NMS can occur with dystonia, unlike motor features, they are less clearly defined, despite their impact on patients' quality of life.[2] In this issue, Ray et al. reviewed the non-motor phenomenology in cervical dystonia (CD).[3] As dystonia is considered to be a spectrum of conditions rather than a single entity, segregation of non-motor phenomenology of this specific dystonia subtype is a challenging exercise. The authors found that the most common NMS associated with CD are anxiety, depression, sleep problems, pain, and sexual dysfunction. While some non-motor features could be linked to motor disturbances and subsequent disability, many of them, such as depression and anxiety, are independent from motor dysfunction and disease duration, suggesting that they may be primary phenotypic components of this condition. Likewise, the lack of a link between cognitive deficits and severity of motor symptoms indicates that mild cognitive decline may also be an independent component of the dystonia spectrum.[4] In the review, Ray et al. point out a range of NMS that may occur in CD, such as cognitive deficits, neuropsychiatric issues as well as sleep dysfunction, including Restless Legs Syndrom.[3] There are also aspects that need to be additionally considered. It is worth noting that some studies have reported that some non-motor characteristics, such as psychiatric disorders or sensory abnormalities, could precede motor symptoms onset, suggesting the presence of a prodromal state also in CD. Other associated non-motor features, such as hyposmia, autonomic dysfunction, and fatigue, are also important and the recently published, comprehensive, and reproducible tool for the early identification of NMS in CD, the Dystonia Non-Motor Symptoms Questionnaire (DNMSQuest), would detect such NMS usually missed in routine consultations.[5] Identification of NMS by using the DNMSQuest could subsequently signpost new mechanistic studies aiming to define whether the neural circuits involved are similar to the perturbated circuits related to motor manifestations (cortico–striatal–thalamo–cortical and cortico–cerebellar circuitry).[4] Of note, as the majority of the NMS highlighted in this review have been linked to a hypo-serotonergic state in Parkinson's disease (depression, anxiety, fatigue, sleep, and sexual dysfunction),[6] it would be intriguing to explore the possible contribution of serotonergic dysfunction also in CD. This could be possible using previous Parkinson's studies as an example.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

1Chaudhuri KR, Healy DG, Schapira AHV. Non-motor symptoms of Parkinson's disease: Diagnosis and management. Lancet Neurol 2006;5:235-45.
2Kuyper DJ, Parra V, Aerts S, Okun MS, Kluger BM. Nonmotor manifestations of dystonia: A systematic review. Mov Disord 2011;26:1206-17.
3Ray S, Pal PK, Yadav R. Non-Motor Symptoms in Cervical Dystonia: A Review. Ann Indian Acad Neurol 2020;23:450-8.
4Loetscher T, McDonnell M. Bradnam, L. Impaired cognitive functioning in cervical dystonia. Hum Neurosci Arch 2015. doi: 10.3389/conf.fnhum.2015.217.00271.
5Klingelhoefer L, Chaudhuri KR, Kamm C, Martinez-Martin P, Bhatia K, Sauerbier A, et al. Validation of a self-completed Dystonia Non-Motor Symptoms Questionnaire. Ann Clin Transl Neurol 2019;6:2054-65.
6Titova N, Padmakumar C, Lewis SJG, Chaudhuri KR. Parkinson's: A syndrome rather than a disease? Journal of Neural Transmission 2017;124:907-14.